Researchers can determine the disease vulnerability of older people using a defined set of substances in the blood Researchers on ageing from the Max Planck Institute for Biology of Ageing and the Leiden University Medical Center (LUMC) collaborate to link basic insights from model organisms to the causes of ageing in humans. They found a combination of biomarkers in the blood which could help estimate the disease vulnerability of elderly people in clinical studies and could possibly be used in intervention studies in model organisms that slow down ageing. When basic researchers investigate the molecular basis of ageing, they usually study model organisms such as worms, fruit flies or mice. The Max Planck Institute for Biology of Ageing aims to link basic insights into ageing to the causes and processes underlying ageing-associated diseases in humans and has therefore recruited Prof. Eline Slagboom from the Leiden University Medical Center in the Netherlands (LUMC) as a Max Planck Fellow in 2018. Now the researchers have identified a set of biomarkers in human blood which could be used in parallel in clinical studies and in ageing research on model organisms. The scientists searched in blood samples of 44,168 individuals for biomarkers that are indicative of a person’s remaining lifespan. After an extensive analysis, the scientists arrived at a set of 14 biomarkers which include for example, various amino acids – the building blocks of proteins – and levels of ‘good’ and ‘bad’ cholesterol, fatty acid balances and inflammation. Clinical studies The blood-based measurement is intended as a first step towards a more personalised treatment of the elderly, explains study director Prof. Eline Slagboom. “As researchers on ageing, we are keen to determine the biological age. The calendar age just doesn’t say very much about the general state of health of elderly people: one 70-year-old is healthy, while another may already be suffering from three diseases. We now have a set of biomarkers which may help to identify vulnerable elderly people, who could subsequently be treated." Model organisms The set of biomarkers is also a starting point for parallel studies in model organisms. “Ageing research in model organisms is ahead of that in humans. To make use of that knowledge we need instruments to compare human and animal studies and this could be one. We are currently investigating if the identified substances can be found in the blood of typical model organisms such as mice and if they are affected by interventions in ageing.”, explains Slagboom. The researchers are now working on answering these questions together with the Cluster of Excellence for Aging Research at the University of Cologne. This large-scale study was possible through collaboration of LUMC with international biobanks, BBMRI-NL (Biobanking and BioMolecular resources Research Infrastructure the Netherlands) and the Max Planck Institute for Biology of Ageing in Cologne. Original publication Joris Deelen, Johannes Kettunen, Krista Fischer, Ashley van der Spek, Stella Trompet, Gabi Kastenmüller, Andy Boyd, Jonas Zierer, Erik B. van den Akker, Mika Ala-Korpela, Najaf Amin, Ayse Demirkan, Mohsen Ghanbari, Diana van Heemst, M. Arfan Ikram, Jan Bert van Klinken, Simon P. Mooijaart, Annette Peters, Veikko Salomaa, Naveed Sattar, Tim D. Spector, Henning Tiemeier, Aswin Verhoeven, Melanie Waldenberger, Peter Würtz, George Davey Smith, Andres Metspalu, Markus Perola, Cristina Menni, Johanna M. Geleijnse, Fotios Drenos, Marian Beekman, J. Wouter Jukema, Cornelia M. van Duijn, P. Eline Slagboom A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals Nature Communications, August 20th, 2019. DOI: 10.1038/s41467-019-11311-9
For 8-million adults who suffer from post-traumatic stress disorder in any given year, medication and cognitive therapy have been the treatment protocol. Now, University of Houston assistant professor of electrical engineering Rose T. Faghih is reporting in Frontiers in Neuroscience that a closed-loop brain stimulator, based on sweat response, can be developed not only for PTSD patients, but also for those who suffer an array of neuropsychiatric disorders. “Sweat primarily helps maintain body temperature; however, tiny bursts of sweat are also released in response to psychologically arousing stimuli. Tracking the associated changes in the conductivity of the skin, which can be seamlessly measured using wearables in real-world settings, thus provides a window into a person’s emotions,” reports Faghih. For people with movement disorders like Parkinson’s disease and essential tremor, who have not responded to medication, application of high-frequency electric current to the brain, or deep brain stimulation, is regarded as most effective. Electrodes are placed in certain areas of the brain to regulate abnormal functions and a pacemaker-like device, placed in the upper chest, controls the amount of stimulation the brain receives. Open-loop stimulators, the most widely-used, deliver continuous stimulation until manually re-adjusted by a physician. Closed-loop stimulators, which provide stimulation in response to biomarkers of pathologic brain activity, have been developed for movement disorders, but are yet to be explored for the treatment of neuropsychiatric disorders. Signaling the onset of a PTSD episode, skin develops the tiniest sheen of perspiration. That symptom of the body’s fight or flight response signals a change in the skin’s electrical conductivity and provides a window into the brain’s state of emotional arousal. Using skin conductance to create the framework for a deep brain stimulator seemed logical to Faghih after reviewing group studies of Vietnam combat veterans with PTSD. Among the findings, PTSD subjects had the largest skin conductance responses when confronted with combat-related words. In a similar study comparing Vietnam combat veterans with and without PTSD and non-combat controls, PTSD veterans had the highest baseline skin conductance levels. “Skin conductance additionally has the advantage of being easily measured with wearable devices that afford convenience, seamless integration into clothing and do not involve risk of surgically implanted sensors,” said Faghih. The ultimate goal will be to develop closed-loop prototypes that can eventually be used for treating patients in a variety of neuropsychiatric disorders. Faghih’s graduate researchers Dilranjan Wickramasuriya and Md. Rafiul Amin were first and second authors, respectively, of the article. This project was supported, in part, by a grant from the National Science Foundation.
A novel neck brace, which supports the neck during its natural motion, was designed by Columbia engineers. This is the first device shown to dramatically assist patients suffering from Amyotrophic Lateral Sclerosis (ALS) in holding their heads and actively supporting them during range of motion. This advance would result in improved quality of life for patients, not only in improving eye contact during conversation, but also in facilitating the use of eyes as a joystick to control movements on a computer, much as scientist Stephen Hawkins famously did. A team of engineers and neurologists led by Sunil Agrawal, professor of mechanical engineering and of rehabilitation and regenerative medicine, designed a comfortable and wearable robotic neck brace that incorporates both sensors and actuators to adjust the head posture, restoring roughly 70% of the active range of motion of the human head. Using simultaneous measurement of the motion with sensors on the neck brace and surface electromyography (EMG) of the neck muscles, it also becomes a new diagnostic tool for impaired motion of the head-neck. Their pilot study was published August 7 in the Annals of Clinical and Translational Neurology. The brace also shows promise for clinical use beyond ALS, according to Agrawal, who directs the Robotics and Rehabilitation (ROAR) Laboratory. "The brace would also be useful to modulate rehabilitation for those who have suffered whiplash neck injuries from car accidents or have from poor neck control because of neurological diseases such as cerebral palsy," he said. "To the best of my knowledge, Professor Agrawal and his team have investigated, for the first time, the muscle mechanisms in the neck muscles of patients with ALS. Their neck brace is such an important step in helping patients with ALS, a devastating and rapidly progressive terminal disease," said Hiroshi Mitsumoto, Wesley J. Howe Professor of neurology at the Eleanor and Lou Gehrig ALS Center at Columbia University Irving Medical Center who, along with Jinsy Andrews, assistant professor of neurology, co-led the study with Agrawal. "We have two medications that have been approved, but they only modestly slow down disease progression. Although we cannot cure the disease at this time, we can improve the patient's quality of life by easing the difficult symptoms with the robotic neck brace." Commonly known as Lou Gehrig's disease, ALS is a neurodegenerative disease characterized by progressive loss of muscle functions, leading to paralysis of the limbs and respiratory failure. Dropped head, due to declining neck muscle strength, is a defining feature of the disease. Over the course of their illness, which can range from several months to more than 10 years, patients completely lose mobility of the head, settling in to a chin-on-chest posture that impairs speech, breathing, and swallowing. Current static neck braces become increasingly uncomfortable and ineffective as the disease progresses. To test this new robotic device, the team recruited 11 ALS patients along with 10 healthy, age-matched subjects. The participants in the study were asked to perform single-plane motions of the head-neck that included flexion-extension, lateral bending, and axial rotation. The experiments showed that patients with ALS, even in the very early stages of the disease, use a different strategy of head-neck coordination compared to age-matched healthy subjects. These features are well correlated with clinical ALS scores routinely used by clinicians. The measurements collected by the device can be used clinically to better assess head drop and the ALS disease progression. "In the next phase of our research, we will characterize how active assistance from the neck brace will impact ALS subjects with severe head drop to perform activities of daily life," said Agrawal, who is also a member of Columbia University's Data Science Institute. "For example, they can use their eyes as a joystick to move the head-neck to look at loved ones or objects around them."
The secret to the success of the ArcWorld cells is as simple as it is effective - take one Motoman robot, a positioning system, controller and power source and combine them in one space-saving platform that can be put straight to use. This ensures the robot cells are easy to install and operate and, if necessary, can also be quickly moved to a new location without any difficulty. The two new and most compact members of the product family to date now make these benefits available in even the smallest of spaces. The ArcWorld RS Mini cell needs just 2.3 square meters of clear floor space, and the ArcWorld HS Micro cell as little as 1.4 square meters. Like their big sisters, the two compact cells come with platform, casing, robot, welding kit and all the necessary accessories included. To satisfy all safety standards, the robot and welding kit are completely encapsulated by a polycarbonate glare shield. And, when it comes to the welding kit itself, customers can choose from a number of suppliers, including Kemppi, Esab and Migatronic. Each of the welding kits available includes a welding power source, cable bundle, wire feeder and welding torch. The system robot is the Motoman AR900, which YASKAWA now also manufactures directly in Europe. Besides exhibiting excellent path accuracy, it also boasts an IP67 protection rating and can therefore be used for welding and other automation tasks in even harsh environments – without requiring any additional modifications. A lean and organic design ensures the robot can reach deep into the working areas, while its smooth surfaces make it easy to clean. The AR900 is controlled via a single cable, which again saves space and also reduces wear. What’s more, this ingenious solution promises to drive down the costs associated with maintenance and spare parts inventories.
Scientists have devised a new computational method that reveals genetic patterns in the massive jumble of individual cells in the body. The discovery, published in the journal eLife, will be useful in discerning patterns of gene expression across many kinds of disease, including cancer. Scientists worked out the formulation by testing tissue taken from the testes of mice. Results in hand, they’re already applying the same analysis to biopsies taken from men with unexplained infertility. Don Conrad Ph.D. (2019) Donald Conrad, Ph.D. “There have been very few studies that attempt to find the cause of any disease by comparing single-cell expression measurements from a patient to those of a healthy control. We wanted to demonstrate that we could make sense of this kind of data and pinpoint a patient’s specific defects in unexplained infertility,” said co-senior author Donald Conrad, Ph.D., associate professor and chief of the Division of Genetics in the Oregon National Primate Research Center at Oregon Health & Science University. Simon Myers, Ph.D., of the University of Oxford, also is a senior co-author. Conrad said he expects the new method will advance the field of precision medicine, where individualized treatment can be applied to the specific nuance of each patient’s genetic readout. The scientists made the breakthrough by applying a method recently developed at the University of Oxford to gene expression data from the massive trove of individual cells comprising even minuscule tissue biopsies. The method is known as sparse decomposition of arrays, or SDA. “Rather than clustering groups of cells, SDA identifies components comprising groups of genes that co-vary in expression,” the authors write. The new study applied the method to 57,600 individual cells taken from the testes of five lines of mice: Four that carry known genetic mutations causing defects in sperm production and one with no sign of genetic infertility. Researchers wanted to see whether it was possible to sort this massive dataset based on the variation in physiological traits resulting from differences in the genes expressed in the RNA, or ribonucleic acid, of individual cells. Researchers found they were able to cut through the statistical noise and sort many thousands of cells into 46 genetic groups. “It’s a data-reduction method that allows us to identify sets of genes whose activity goes up and down over subsets of cells,” Conrad said. “What we’re really doing is building a dictionary that describes how genes change at a single-cell level.” The work will immediately apply to male infertility. Infertility affects an estimated 0.5% to 1% of the male population worldwide. Current measures to treat male infertility involve focus on managing defects in the sperm itself, including through in vitro fertilization. However, those techniques don’t work in all cases. “We’re talking about the problem where you don’t make sperm to begin with,” Conrad said. This new technique could open new opportunities to diagnose a specific genetic defect and then potentially rectify it with new gene-editing tools such as CRISPR. Identification of a specific cause would be a vast improvement over the current state of the art in diagnosing male infertility, which amounts to a descriptive analysis of testicular tissue biopsies. “The opportunity provided by CRISPR, coupled to this kind of diagnosis, is really a match made in heaven,” Conrad said. This work was supported by National Institutes of Health grants R01HD078641 and R01MH101810; Wellcome Trust grants 098387/Z/12/Z and 212284/Z/18/Z and 109109/Z/15/Z. Research was further supported by the NIH Office of the Director to the Oregon National Primate Research Center, Award No. P510D011092.
A technology that can obtain high-resolution, micrometer-sized images for mass spectrometric analysis without sample preparation has been developed. DGIST Research Fellow Jae Young Kim and Chair-professor Dae Won Moon’s team succeeded in developing the precise analysis and micrometer-sized imaging of bio samples using a small and inexpensive laser. DGIST announced that Research Fellow Jae Young Kim in the Department of Robotics Engineering and Chair-professor Dae Won Moon’s team developed a technology that can analyze experiment samples without any preparation processing. Due to its ability to obtain high-resolution mass spectrometric images without an experimental environment using ‘continuous wave laser’1, the technology is expected to be applied widely in the precise medicine and medical diagnosis fields. Many advance preparations are needed for the mass spectrometric imaging of biometric samples using ‘specimen,’ which thinly cut an object to analyze. The specimen must be changed artificially since they cannot be analyzed accurately in a room temperature or atmospheric pressure. To develop a convenient analysis technology and ease the burden, Research Fellow Kim started the research. The research team installed a lens carrying continuous wave laser right below a microscope substrate where the specimen is put and shot the laser on it to measure mass spectra by examining molecules from desorption2. The mass spectra can be analyzed through a continuous wave laser whose energy is weaker than other lasers because of the use of ‘graphene substrate’ below the specimen. Since the honeycomb-patterned graphene has very high heat conductivity and can convert light into heat, it can secure enough heat needed for specimen analysis with small amount of light generated by the continuous wave laser. This technology is also advantageous for obtaining high-resolution analysis images, because it can secure space to observe specimen much more closely even when using a 20x magnifying lens. Chair-professor Dae Won Moon in the Department of New Biology explained that “Through this technology, we could greatly shorten the preparation time for analysis by omitting the specimen preprocessing step. Our next plan is to develop the technology further so it can be applied in various areas such as medical diagnosis.” This research was participated by Research Fellow Jae Young Kim in the Department of Robotics Engineering and Ph.D. candidate Heejin Lim in the Department of New Biology as the co-first authors and was conducted with Professor Cheol Song in the Department of Robotics Engineering at DGIST, Professor Dong-Kwon Lim at Korea University, and Research Professor Ji-Won Park at Chungnam National University. The results were published as the cover paper on “ACS Applied Materials & Interfaces,” an international journal in the chemical and nano-technology field, on July 31. 1 Continuous wave laser: Emits laser beam continuously, is smaller and cheaper than pulse-type laser, and has a simple structure. Also referred to as ‘CW laser.’ 2 Desorption: Molecules absorbed on a solid surface fall off from the surface due to heat, light, electronic shock, etc. For more information, contact: Dae Won Moon, Chair Professor Department of New Biology Daegu Gyeongbuk Institute of Science and Technology (DGIST) E-mail: email@example.com Associated Links Research Paper in Journal of ACS Applied Materials & Interfaces https://pubs.acs.org/doi/10.1021/acsami.9b02620 Journal Reference Jae Young Kim, Heejin Lim, Sun Young Lee, Cheol Song, Ji-Won Park, Hyeon Ho Shin, Dong-Kwon Lim, and Dae Won Moon, "Graphene-Coated Glass Substrate for Continuous Wave Laser Desorption and Atmospheric Pressure Mass Spectrometric Imaging of Live Hippocampal Tissue", ACS Applied Materials & Interfaces, Published on July, 2019.
Researchers have developed a new method for producing malleable microstructures -- for instance, vascular stents that are 40 times smaller than previously possible. In the future, such stents could be used to help to widen life-threatening constrictions of the urinary tract in fetuses in the womb. Approximately one in every thousand children develops a urethral stricture, sometimes even when they are still a fetus in the womb. In order to prevent life-threatening levels of urine from accumulating in the bladder, paediatric surgeons like Gaston De Bernardis at the Kantonsspital Aarau have to surgically remove the affected section of the urethra and sew the open ends of the tube back together again. It would be less damaging to the kidneys, however, if a stent could be inserted to widen the constriction while the fetus is still in the womb. Stents have been used to treat blocked coronary vessels for some time now, but the urinary tract in foetuses is much narrower in comparison. It's not possible to produce stents with such small dimensions using conventional methods, which is why De Bernardis approached the Multi-Scale Robotics Lab at ETH Zurich. The lab's researchers have now developed a new method that enables them to produce highly detailed structures measuring less than 100 micrometres in diameter, as they report in a recently published journal article. Indirect 4D printing "We've printed the world's smallest stent with features that are 40 times smaller than any produced to date," says Carmela De Marco, lead author of the study and Marie Sk?odowska-Curie fellow in Bradley Nelson's research group. The group calls the method they've developed indirect 4D printing. They use heat from a laser beam to cut a three-dimensional template -- a 3D negative -- into a micromould layer that can be dissolved with a solvent. Next, they fill the negative with a shape-memory polymer and set the structure using UV light. In the final step, they dissolve the template in a solvent bath and the three-dimensional stent is finished. It's the stent's shape-memory properties that give it its fourth dimension. Even if the material is deformed, it remembers its original shape and returns to this shape when warm. "The shape-memory polymer is suitable for treating urethral strictures. When compressed, the stent can be pushed through the affected area. Then, once in place, it returns to its original shape and widens the constricted area of the urinary tract," De Bernardis says. But the stents are still a long way from finding real-world application. Before human studies can be conducted to show whether they are suitable for helping children with congenital urinary tract defects, the stents must first be tested in animal models. However the initial findings are promising, "We firmly believe that our results can open the door to the development of new tools for minimally invasive surgery," De Marco says.
Purdue University researchers have developed a new fabric innovation that allows wearers to control electronic devices through clothing. "It is the first time there is a technique capable to transform any existing cloth item or textile into a self-powered e-textile containing sensors, music players or simple illumination displays using simple embroidery without the need for expensive fabrication processes requiring complex steps or expensive equipment," said Ramses Martinez, an assistant professor in the School of Industrial Engineering and in the Weldon School of Biomedical Engineering in Purdue's College of Engineering. The technology is featured in the July 25 edition of Advanced Functional Materials. "For the first time, it is possible to fabricate textiles that can protect you from rain, stains, and bacteria while they harvest the energy of the user to power textile-based electronics," Martinez said. "These self-powered e-textiles also constitute an important advancement in the development of wearable machine-human interfaces, which now can be washed many times in a conventional washing machine without apparent degradation. Martinez said the Purdue waterproof, breathable and antibacterial self-powered clothing is based on omniphobic triboelectric nanogeneragtors (RF-TENGs) -- which use simple embroidery and fluorinated molecules to embed small electronic components and turn a piece of clothing into a mechanism for powering devices. The Purdue team says the RF-TENG technology is like having a wearable remote control that also keeps odors, rain, stains and bacteria away from the user. "While fashion has evolved significantly during the last centuries and has easily adopted recently developed high-performance materials, there are very few examples of clothes on the market that interact with the user," Martinez said. "Having an interface with a machine that we are constantly wearing sounds like the most convenient approach for a seamless communication with machines and the Internet of Things." The technology is being patented through the Purdue Research Foundation Office of Technology Commercialization. The researchers are looking for partners to test and commercialize their technology. Their work aligns with Purdue's Giant Leaps celebration of the university's global advancements in artificial intelligence and health as part of Purdue's 150th anniversary. It is one of the four themes of the yearlong celebration's Ideas Festival, designed to showcase Purdue as an intellectual center solving real-world issues.
While the presence of beta-amyloid plaques in the brain may be a hallmark of Alzheimer’s disease, giving patients an amyloid PET scan is not an effective method for measuring their cognitive function, according to a new study from researchers in the Perelman School of Medicine and Thomas Jefferson University. The researchers concluded that fluorodeoxyglucose (FDG) PET, which measures the brain’s glucose consumption as a marker of neural activity, is a stronger approach for assessing the progression and severity of Alzheimer’s and mild cognitive impairment (MCI) as compared to florbetapir-PET scans, which reveal amyloid protein deposits in the brain. This suggests that FDG-PET is also a better means for determining the effectiveness of Alzheimer’s therapies, as well as tracking patients’ disease advancement, in both clinical and research settings. Results of this study are detailed in the August issue of the Journal of Alzheimer’s Disease. PET imaging using the radiotracers FDG and florbetapir to quantify cognitive decline in patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and healthy controls. (Image: Penn Medicine News) “Both florbetapir-PET and FDG-PET are approved diagnostic methods for Alzheimer’s disease, and both appear to be effective in indicating some sort of cognitive impairment. However, we have now shown that FDG-PET is significantly more precise in clinical studies, and it is also available for routine use with modest costs,” says the study’s co-principal investigator Abass Alavi, a professor of radiology at Penn. “Our results support the notion that amyloid imaging does not reflect levels of brain function, and therefore it may be of limited value for assessing patients with cognitive decline.” Two of the most significant biomarkers found in Alzheimer’s are decreased glucose uptake and the accumulation of amyloid plaques in the brain. PET scans use different radioactive drugs, called radiotracers, to measure these biomarkers within the brain tissue of patients with cognitive impairment. FDG-PET is one of the most commonly used imaging techniques to diagnose Alzheimer’s. However, in recent years, several other radiotracers, such as florbetapir, have been developed to detect the deposition of amyloid plaques. Recently, the effectiveness of amyloid imaging as a strategy for monitoring dementia symptoms has been called into question.
Certain traits may define a type of obstructive sleep apnea that can be effectively treated with an oral appliance, according to new research published online in the Annals of the American Thoracic Society. With OSA there are times during sleep when air cannot flow normally into the lungs. The collapse of the soft tissues in the back of the throat or tongue usually causes the airflow obstruction. Continuous positive airway pressure, or CPAP, is considered the gold standard for preventing the obstruction by blowing air through a mask into the nose and throat. However, many patients have trouble sleeping with CPAP. For these patients, an oral appliance that moves the lower jaw forward to prevent the periods of obstructed airflow is often an alternative. In "Polysomnographic Endotyping to Select Obstructive Sleep Apnea Patients for Oral Appliances," Ahmad A. Bamagoos and colleagues identify five traits that appear to determine the effectiveness of an oral appliance in treating OSA. "Sleep apnea is not all the same, but we only recently developed ways to look at a sleep study and determine what traits cause the condition in different patients," said senior author Scott Sands, PhD, assistant professor of medicine at Harvard Medical School and Brigham and Women's Hospital in Boston. "Since oral appliances work by improving the collapsibility of the upper airway, patients without really severe collapsibility are more likely to benefit from an oral appliance, while those with sleep apnea caused by other traits, such as exaggerated reflex responses to drops in oxygen levels, are less likely to benefit." The researchers used their new technology to measure the traits causing sleep apnea through polysomnography, the test used to diagnose sleep apnea. For this study, the researchers analyzed polysomnographic data already gathered from 93 adults (average age: 56) who were diagnosed with moderate to severe OSA. The authors looked at two traits related to the upper airway: collapsibility and muscle compensation. The researchers found that patients without severe collapsibility benefitted more from the oral appliance than those without this trait. Those with a weaker reflex response of the throat muscles that act to maintain an open airway (lower muscle compensation) also benefitted more than those with a stronger reflex response. Patients with very mild collapsibility, indicating deficits in other traits, responded less well. The researchers also found that three traits unrelated to the upper airway helped predict those patients who would respond less well to an oral appliance: higher loop gain, lower arousal threshold and higher ventilatory response to arousal. Loop gain is a measure of how aggressively the brain and lungs respond to falling oxygen and rising carbon dioxide in the blood. Arousal threshold is a measure of how easily a person wakes up from sleep; deeper sleep (higher arousal threshold) promotes better breathing. Based on these five traits, oral appliances were predicted to be effective in treating sleep apnea in more than half (61 percent) of the participants. Patients in this group experienced a 73 percent reduction in the Apnea-Hypopnea Index, which is the number of breathing pauses per hour lasting 10 seconds or longer. (Apnea means no airflow and hypopnea means reduction in airflow). With an oral appliance, they had just eight apneas/hypopneas per hour. The other patient group experienced a smaller reduction in the Apnea-Hypopnea Index and had twice the number of breathing pauses remaining with the oral appliance. The authors said that responses to oral appliances in their study could not be predicted by the severity of sleep apnea or how overweight patients were. "Surprisingly, it didn't seem to matter whether sleep apnea was moderate or very severe," Dr. Sands said. "Oral appliance therapy was remarkably effective in some quite overweight patients with very severe OSA." Based on these findings, the authors write that, if their results are upheld in future studies, an oral appliance could be considered, along with CPAP, as a first-line therapy for treating a certain type of OSA. "While CPAP is great for some, there remains a large group of patients who really struggle with it," Dr. Sands said. "For these folks, this study highlights the potential benefit of measuring the underlying causes of their sleep apnea to estimate whether an oral appliance might be an equivalent or better choice over CPAP for the treatment of their sleep apnea." Dr. Sands added that once the most useful measures for predicting patient outcomes are established, he believes they will be readily incorporated into routine sleep recording systems.